The Science Behind Cannabinoids
AT CULTIVATE BIOLOGICS WE KNOW
All Cannabinoids
Are Not the Same
AT CULTIVATE BIOLOGICS WE KNOW
All Cannabinoids
Are Not the Same
The Science Behind Cannabinoids
The Endocannabinoid System
All mammals have an endocannabinoid system (ECS) which is one of the oldest systems in the mammalian body and is responsible for maintaining homeostasis, or balance. Whatever is not functioning as it should, whether that be an inflammatory response, a cognitive issue, or a digestive issue is brought back into balance by the ECS. Cannabinoid receptors are found throughout the brain and body and are activated when CBD + CBDA, terpenes, and the minor cannabinoids are introduced in the body.
Endocannabinoid System Receptors
There are several receptors involved with the ECS, the most well known of which are CB1 and CB2 receptors, but the TRPV1, GPR55, and PPAR receptors though not traditionally thought to be part of the endocannabinoid system, are intimately involved in the regulation of the endocannabinoid system. When the body needs to address an imbalance, the specific receptors for that issue are activated, and CBD+CBDA as well as other minor cannabinoids stimulates the response.
Terpenes
Terpenes are additional compounds found in the hemp plant and are best known for their smell. However, they are important in other ways, such as promoting calm or helping with an anti-inflammatory response. Terpenes work together with cannabinoids to work synergistically to create an overall better effect, which is called the entourage effect.
The Endocannabinoid System
All mammals have an endocannabinoid system (ECS) which is one of the oldest systems in the mammalian body and is responsible for maintaining homeostasis, or balance. Whatever is not functioning as it should, whether that be an inflammatory response, a cognitive issue, or a digestive issue is brought back into balance by the ECS. Cannabinoid receptors are found throughout the brain and body and are activated when CBD + CBDA, terpenes, and the minor cannabinoids are introduced in the body.
Endocannabinoid System Receptors
There are several receptors involved with the ECS, the most well known of which are CB1 and CB2 receptors, but the TRPV1, GPR55, and PPAR receptors though not traditionally thought to be part of the endocannabinoid system, are intimately involved in the regulation of the endocannabinoid system. When the body needs to address an imbalance, the specific receptors for that issue are activated, and CBD+CBDA as well as other minor cannabinoids stimulates the response.
Terpenes
Terpenes are additional compounds found in the hemp plant and are best known for their smell. However, they are important in other ways, such as promoting calm or helping with an anti-inflammatory response. Terpenes work together with cannabinoids to work synergistically to create an overall better effect, which is called the entourage effect.
What is the Endocannaboid System?
The endocannabinoid system (ECS) is an important system in the body of every mammal. The ECS is one of the largest receptor systems in the body. It functions both as an immunomodulatory and a neuromodulatory system and is essential for stress recovery as well as maintaining homeostasis in the body, or making sure everything is in balance. There is virtually no physiological or cognitive process that isn’t related in some manner to the ECS. The ECS is composed of endogenous lipid-based signaling molecules which bind to cannabinoid receptors. The body has many important systems that appear to be affected by “endocannabinoid tone” with the most work being done at understanding the endocannabinoids in the central nervous system and the immune systems. Somehow, the endocannabinoid system was unknown, overlooked, and generally not a part of the medical or veterinary school curriculum due to a lack of research in clinical patients, which explains why healthcare providers have not taken advantage of the vital role cannabinoids play in maintaining balance in the body. Simply put, whatever is out of balance, whether it be itching, an inflammatory response, discomfort, cognitive issues, the endocannabinoid system’s job is to address the imbalance and get back to normal.
What is the Endocannaboid System?
The endocannabinoid system (ECS) is an important system in the body of every mammal. The ECS is one of the largest receptor systems in the body. It functions both as an immunomodulatory and a neuromodulatory system and is essential for stress recovery as well as maintaining homeostasis in the body, or making sure everything is in balance. There is virtually no physiological or cognitive process that isn’t related in some manner to the ECS. The ECS is composed of endogenous lipid-based signaling molecules which bind to cannabinoid receptors. The body has many important systems that appear to be affected by “endocannabinoid tone” with the most work being done at understanding the endocannabinoids in the central nervous system and the immune systems. Somehow, the endocannabinoid system was unknown, overlooked, and generally not a part of the medical or veterinary school curriculum due to a lack of research in clinical patients, which explains why healthcare providers have not taken advantage of the vital role cannabinoids play in maintaining balance in the body. Simply put, whatever is out of balance, whether it be itching, an inflammatory response, discomfort, cognitive issues, the endocannabinoid system’s job is to address the imbalance and get back to normal.
Full Spectrum Hemp
Full-spectrum CBD contains all of the cannabinoids, terpenes, flavonoids and fatty acids found in the entire hemp plant.
Cannabis, with its complex chemical structure, contains over 140 active cannabinoids aside from CBD. It also contains terpenes, which have anti-inflammatory properties, and are regarded as increasing the efficacy of cannabinoids. Although they are not rated as important as CBD when it comes to health benefits, some of the lesser known cannabinoids have been shown to positively support overall health.
Full Spectrum Hemp
Full-spectrum CBD contains all of the cannabinoids, terpenes, flavonoids and fatty acids found in the entire hemp plant.
Cannabis, with its complex chemical structure, contains over 140 active cannabinoids aside from CBD. It also contains terpenes, which have anti-inflammatory properties, and are regarded as increasing the efficacy of cannabinoids. Although they are not rated as important as CBD when it comes to health benefits, some of the lesser known cannabinoids have been shown to positively support overall health.
The Entourage Effect
Because all the cannabinoids are present, users tend to experience what is known as, the entourage effect. This means all the different cannabinoids work together, boosting each cannabinoid effect which creates a product that has improved therapeutic benefits that are more effective than CBD isolated products.
Studies in analgesia have show that pure CBD produces a biphasic dose-response curve where smaller doses reduce pain responses until a peak is reached and further increase in dose are ineffective or even counterproductive. Interestingly, complete spectrum extracts with equivalent dosing doses of CBD do not show a biphasic response but a linear dose-response curve such that the botanical blend is analgesic at any dose with no observed ceiling (Gallily, 2015; Russo, 2018)
The Entourage Effect
Because all the cannabinoids are present, users tend to experience what is known as, the entourage effect. This means all the different cannabinoids work together, boosting each cannabinoid effect which creates a product that has improved therapeutic benefits that are more effective than CBD isolated products.
Studies in analgesia have show that pure CBD produces a biphasic dose-response curve where smaller doses reduce pain responses until a peak is reached and further increase in dose are ineffective or even counterproductive. Interestingly, complete spectrum extracts with equivalent dosing doses of CBD do not show a biphasic response but a linear dose-response curve such that the botanical blend is analgesic at any dose with no observed ceiling (Gallily, 2015; Russo, 2018)
Full Power of the Plant
THC and CBD have received the most attention to date, but the minor cannabinoids are proving to have tremendous potential for therapeutic purposes.
Because of our profound belief in the entourage effect we focus on creating unique blends with minor cannabinoids such as CBDA, CBG, CBGA, CBDV, CBDVA, THCVA, THCV and CBN as part of a full spectrum extract rich in terpenes such as α-pinene, β-myrcene and β-caryophyllene. These blends can be fully customizable depending on the therapeutic purpose.
Full Power of the Plant
THC and CBD have received the most attention to date, but the minor cannabinoids are proving to have tremendous potential for therapeutic purposes.
Because of our profound belief in the entourage effect we focus on creating unique blends with minor cannabinoids such as CBDA, CBG, CBGA, CBDV, CBDVA, THCVA, THCV and CBN as part of a full spectrum extract rich in terpenes such as α-pinene, β-myrcene and β-caryophyllene. These blends can be fully customizable depending on the therapeutic purpose.
Ongoing Studies / Research
Cultivate is committed to putting science first in everything that we do. Our oils have been used in more than 20 clinical studies and R&D projects with multiple prestigious universities such as Johns Hopkins Medicine, Washington State and Oregon State. We believe that the research we are conducting in genomics as well as the impact of our formulations on various human conditions will not only give you more confidence in our products but more importantly result in breakthrough and foundational scientific discoveries that will change the field of Hemp and Cannabinoid science.
Ongoing Studies / Research
Cultivate is committed to putting science first in everything that we do. Our oils have been used in more than 20 clinical studies and R&D projects with multiple prestigious universities such as Johns Hopkins Medicine, Washington State and Oregon State. We believe that the research we are conducting in genomics as well as the impact of our formulations on various human conditions will not only give you more confidence in our products but more importantly result in breakthrough and foundational scientific discoveries that will change the field of Hemp and Cannabinoid science.